The pharmacokinetics and protein binding of propofol were studied in ten patients with cirrhosis and in ten control patients undergoing elective surgery. All patients received 2.5 mg.kg-1 propofol as an intravenous bolus injection for the induction of anesthesia. Whole blood propofol concentrations …

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1 Propofol lipid emulsion has been associated with a variety of drawbacks for which altered lipid emulsion or nonemulsion formulations have been developed. 2 2018-07-18 We have compared the pharmacokinetics of propofol as an infusion in 10 control and 10 patients with cirrhosis. Anaesthesia was induced within 3-4 min during administration of an infusion of propofol 21 mg kg-1 h-1. After 5 min, the infusion was decreased in a stepwise manner to 12 mg kg-1 h-1 and subsequently 6 mg kg-1 h-1.

Whole blood propofol concentrations … The hypothesis that the propofol-in-cyclodextrin formulation would exhibit pharmacokinetic and pharmacodynamic behavior that was substantially similar to the propofol-in-lipid formulation was confirmed.IMPLICATIONS: A modified cyclodextrin-based formulation of propofol has been developed that may mitigate some of the problems associated with propofol in lipid emulsion. Propofol pharmacokinetics, with or without 2% benzyl alcohol, were characterized by rapid distribution, a long elimination phase, and a large volume of distribution. No differences were noted between treatments with the exception of clearance from the second compartment (CLD2), which was 23.6 and 38.8 mL kg(-1) minute(-1) in the P and P28 treatments, respectively. Using propofol as an example, explain briefly the importance of clearance. (also Pharm-97A10, Pharm-95B01) Pharm-00A14 Discuss the roles of the plasma esterases on drugs used in anaesthesia.

av M Lindqvist · 2015 — describe the variations in propofol pharmacokinetics. Postoperative cognitive recovery in women undergoing ambulatory breast cancer surgery with propofol or

Keywords: anaesthetics i.v., propofol; obesity; pharmacokinetics Accepted for publication: 17 May 2010 Keywords propofol infusion pharmacokinetics Introduction Early pharmacokinetic studies of the intra-venous anaesthetic agent propofol, administered as a single i.v. bolus dose, have suggested that this agentwaseliminated veryrapidly fromthe body.

Farmakokinetiska begrepp. Pharmacokinetics: Farmakokinetik beskriver vad kroppen gör med läkemedlet. Kvantitativ analys av processer som

Kvantitativ analys av processer som av A Woldegiorgis · 2007 · Citerat av 6 — Propofol. Clozapin. Zolpidem.

Pharmacokinetics of propofol in adult patients undergoing coronary revascularization. Anesthesiology: The Journal of the American Society of Anesthesiologists. 1996 Jun 1;84(6):1288e97. Open-TCI Billard 1998 Propofol 51 Venous 29e69 40e89 Alfentanil SFAR abstract 1998, poster R279 Open-TCI Conclusions: Pharmacokinetics of propofol can be well described by a three-compartment model. Inclusion of age and weight as covariates significantly improved the model.
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The pharmacokinetics of propofol and alfentanil, in the absence of other drugs, have been described by several investigators and for various patient populations.

Caution should be exerted when using propofol. TCI in patients with frontal brain tumours 13 Mar 2008 Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age. K Allegaert,; M Peeters, 17 May 2012 Objectives: To analyze population pharmacokinetics of Propofol in Indian patients after single bolus dose of Propofol using WINNONLIN Abstract Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia.
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WITH ETOMIDATE, FENTANYL, MIDAZOLAM, PROPOFOL, THIOPENTAL, AND keywords = "PANCURONIUM, ANESTHESIA, PHARMACOKINETICS,

Propofol blood 8 Jun 2015 Poor understanding of the pharmacokinetics of target-controlled A variety of pharmacokinetic models for propofol and remifentanil have been 17 Jan 2020 The Effect of UGT1A9, CYP2B6 and CYP2C9 Genes Polymorphism on Propofol Pharmacokinetics in Children Dimitrije Pavlovic, 1 Ivana Budic, 13 Aug 2018 Under 4 h anesthesia with propofol target-controlled infusion in our Regarding the pharmacokinetics of propofol, sex has been reported to 21 Apr 2010 Sedation for gastrointestinal endoscopies is obtained by opioids, benzodiazepines, propofol, ketamine and/or droperidol. The pharmacokinetic 21 Oct 2017 As a result, anaesthetic pharmacokinetics must be described using models Let's consider the case of propofol, using the pharmacokinetics Like most intravenous anesthetics, Propofol works by increasing GABA-mediated inhibatory tone in the CNS. Propofol decreases the rate of dissociation of the Pharmacokinetics models with propofol were developed for many species like rats [7,9], pigs [25], dogs [26], cats [27] and rabbits [8,28].